Higher filtration fraction in formerly early-onset preeclamptic women without comorbidity
| Autor: | Marijke M. Faas, Tsjitske J. Toering, Anne Marijn van der Graaf, Folkert W. Visser, Gerjan Navis, A. Titia Lely, Henk Groen |
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| Přispěvatelé: | Methods in Medicines evaluation & Outcomes research (M2O), Reproductive Origins of Adult Health and Disease (ROAHD), Translational Immunology Groningen (TRIGR), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), Value, Affordability and Sustainability (VALUE) |
| Rok vydání: | 2015 |
| Předmět: |
renal hemodynamics
Physiology Hemodynamics Blood Pressure BLOOD-PRESSURE Comorbidity Kidney Renin-Angiotensin System Pre-Eclampsia Risk Factors postpartum Infusions Intravenous Netherlands Medicine(all) Cross-Over Studies Angiotensin II STAGE RENAL-DISEASE GLOMERULAR HYPERFILTRATION ASSOCIATION Diet Sodium-Restricted Renal hemodynamics renin-angiotensin-aldosterone system PREGNANCY HEMODYNAMICS Cardiology Female Glomerular hyperfiltration Glomerular Filtration Rate Adult medicine.medical_specialty Urology Na+ intake Gestational Age White People Preeclampsia preeclampsia Predictive Value of Tests Postpartum Internal medicine medicine Humans ANGIOTENSIN-II SENSITIVITY Pregnancy Dose-Response Relationship Drug business.industry Renin-angiotensinaldosterone system Sodium Dietary medicine.disease Renal Plasma Flow Effective Filtration fraction BODY-MASS INDEX SODIUM Endocrinology Blood pressure HYPERTENSIVE DISORDERS Kidney Failure Chronic business Body mass index |
| Zdroj: | American Journal of Physiology-Renal Physiology, 308(8), 824. American Physiological Society American journal of physiology-Renal physiology, 308(8), F824-F831. AMER PHYSIOLOGICAL SOC |
| ISSN: | 1522-1466 1931-857X 0363-6127 |
| Popis: | Formerly preeclamptic women have an increased risk for developing end-stage renal disease, which has been attributed to altered renal hemodynamics and abnormalities in the renin-angiotensin-aldosterone system. Whether this is due to preeclampsia itself or to comorbid conditions is unknown. Renal hemodynamics and responsiveness to ANG II during low Na+intake (7 days, 50 mmol Na+/24 h) and high Na+(HS) intake (7 days, 200 mmol Na+/24 h) were studied in 18 healthy normotensive formerly early-onset preeclamptic women (fPE women) and 18 healthy control subjects (fHP women), all selected for absence of comorbidity. At the end of each diet, renal hemodynamics and blood pressure were measured before and during graded ANG II infusion. Both HS intake and former preeclampsia increased filtration fraction (FF) without an interaction between the two. FF was highest during HS intake in fPE women [0.31 ± 0.12 vs. 0.29 ± 0.11 in fHP women, generalized estimating equation analysis (body mass index corrected), P = 0.03]. The renal response to ANG II infusion was not different between groups. In conclusion, fPE women have a higher FF compared with fHP women. As this was observed in the absence of comorbidity, preeclampsia itself might exert long-term effects on renal hemodynamics. However, we cannot exclude the presence of prepregnancy alterations in renal function, which, in itself, lead to an increased risk for preeclampsia. In experimental studies, an elevated FF has been shown to play a pathogenic role in the development of hypertension and renal damage. Future studies, however, should evaluate whether the subtle differences in renal hemodynamics after preeclampsia contribute to the increased long-term renal risk after preeclampsia. |
| Databáze: | OpenAIRE |
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