Pharmacokinetics of ampicillin, sulbactam and cefotiam in patients undergoing orthopedic surgery
| Autor: | E Hille, H Gotthardt, A Wildfeuer, J Mallwitz, H Gruber, G Pfaff, G Dahmen, C Göbel |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Microbiology (medical)
Adult Male Prosthesis-Related Infections Ampicillin/sulbactam Drug Administration Schedule Cefotiam Pharmacokinetics Ampicillin medicine Humans Antibiotic prophylaxis Infusions Intravenous Antibacterial agent Aged Aged 80 and over business.industry General Medicine Sulbactam Perioperative biochemical phenomena metabolism and nutrition Antibiotic Prophylaxis Middle Aged Anti-Bacterial Agents Infectious Diseases Treatment Outcome Anesthesia Female Hip Prosthesis business Knee Prosthesis medicine.drug |
| Zdroj: | Infection. 25(4) |
| ISSN: | 0300-8126 |
| Popis: | As perioperative prophylaxis for major orthopedic operations 81 patients were given the fixed combination of ampicillin (1 g)/sulbactam (0.5 g) or cefotiam (2 g) as short infusions. The three beta-lactams were rapidly distributed into the different tissues and their pharmacokinetic profiles were found to be very similar. It was noteworthy that ampicillin, sulbactam and cefotiam penetrated within minutes, not only into skin, fat and muscles, but also into bone. Thus 0.25 h after starting the infusion the following mean concentrations were measured in bone: 21.8 +/- 10.5 mg/kg ampicillin, 4.9 +/- 2.2 mg/kg sulbactam and 19.4 +/- 10.6 mg/kg cefotiam. For a period of at least 2 h the concentrations measured in serum and in the different tissues affected by the operation (skin, fat, muscle, bone) were above the MICs for pathogens which are involved in postoperative wound infections. On the basis of pharmacokinetic data, ampicillin/sulbactam and cefotiam seem about equally suitable for perioperative prophylaxis in major orthopedic operations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink