In Vitro Release of Cisplatin from Sol-Gel Processed Porous Silica Xerogels

Autor:	J Lukasiak, Katarzyna Czarnobaj
Rok vydání:	2004
Předmět:	Cisplatin Materials science Silicon dioxide Silica gel Silica Gel Pharmaceutical Science Nanotechnology General Medicine Silicon Dioxide Phase Transition In vitro Matrix (chemical analysis) chemistry.chemical_compound Chemical engineering chemistry Phase (matter) medicine Porosity Sol-gel medicine.drug
Zdroj:	Drug Delivery. 11:341-344
ISSN:	1521-0464 1071-7544
DOI:	10.1080/10717540490507451
Popis:	Cisplatin an antineoplastic medicine, was incorporated into a silica gel received by the sol-gel method. Various techniques of trapping an active substance in gel were applied: at the stage of sol creation--by the predoping method--and already upon receipt of hard xerogel--the postdoping method. Further, the research aimed at the determination of the dynamics of cisplatin release from sol-gel processed silica xerogel to the water phase. Based on the achieved results, we may state that the sol-gel method is useful for trapping a medicine like cisplatin in silica gel and gives repeatable results with regard to medicine release from the pores of the so-established matrix. The postdoping method appeared to be more beneficial, because the gained gel's active substance is released almost entirely (94-96%). The time of release was 3 days.
Databáze:	OpenAIRE
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