Placental Passage of Antibodies to Dengue Virus in Persons Living in a Region of Hyperendemic Dengue Virus Infection
| Autor: | A K Ventura, D Rosenthal, N J Ehrenkranz |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
Immunodiffusion Adolescent Placenta Dengue virus Antibodies Viral medicine.disease_cause Umbilical cord Immunoglobulin G Virus Dengue fever Dengue Pregnancy medicine Humans Immunology and Allergy Child Antigens Viral Maternal-Fetal Exchange Rubella biology Complement Fixation Tests Dominican Republic Infant Newborn Infant Dengue Virus Hemagglutination Inhibition Tests Fetal Blood medicine.disease Virology Immunoglobulin A Infectious Diseases medicine.anatomical_structure Immunoglobulin M Child Preschool Antibody Formation Immunology biology.protein Female Antibody Rubella virus Arboviruses Encephalitis |
| Zdroj: | Journal of Infectious Diseases. 131:S62-S68 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/131.supplement.s62 |
| Popis: | Maternal and umbilical cord levels of antibodies to dengue 2 and 3 viruses were compared in 54 matched pairs of specimens from subjects in the Dominican Republic. Dengue infection appeared to be hyperendemic; pregnant women experienced a 6% weekly infection rate. Titers of antibody to dengue 2 and 3 viruses were considerably higher in cord sera than in maternal sera (P smaller than 0.001 and P smaller 0.01, respectively), especially when maternal levels were low. When maternal and cord sera were compared at equal titers of dengue 2 virus, heterotypic antibodies to dengue 1 and St. Louis encephalitis viruses were higher in the cord. These findings could not be directly related to the higher levels of IgG found in cord sera or to the presence of elevated concentrations of IgM. It is concluded that antibody with increased cross-reactivity preferentially crosses the placenta. The presence of such cross-reactive antibody does not appear to sensitize infants to dengue hemorrhagic fever/shock syndrome. |
| Databáze: | OpenAIRE |
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