IL-21 enhances influenza vaccine responses in aged macaques with suppressed SIV infection
| Autor: | Constantinos Petrovas, Alexander Kizhner, Francois Villinger, Daniel Kvistad, Rajendra Pahwa, Savita Pahwa, Tirupataiah Sirupangi, Suresh Pallikkuth |
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| Rok vydání: | 2021 |
| Předmět: |
Influenza vaccine
T cell Adaptive immunity Population Simian Acquired Immunodeficiency Syndrome medicine.disease_cause Virus AIDS/HIV TIGIT medicine Animals education Vaccines education.field_of_study business.industry Interleukins Germinal center General Medicine Simian immunodeficiency virus Acquired immune system Macaca mulatta Influenza medicine.anatomical_structure Influenza Vaccines Immunology Immunotherapy business Research Article |
| Zdroj: | JCI Insight |
| ISSN: | 2379-3708 |
| Popis: | Natural aging and human immunodeficiency virus (HIV) infection are associated with chronic low-grade systemic inflammation, immune senescence, and impaired antibody (Ab) responses to vaccines such as influenza (flu). We investigated the role of Interleukin (IL)-21, a CD4 T follicular helper cells (Tfh) regulator, on flu vaccine Ab response in non-human primates (NHPs) in the context of age and controlled simian immunodeficiency virus (SIV) mac239 infection. Three doses of the flu vaccine with or without IL-21-IgFc were administered at 3-month intervals in aged SIV+ NHPs following virus suppression with anti-retroviral therapy. IL-21 treated animals demonstrated higher day 14 post-boost Ab responses which associated with expanded CD4+ T CM cells and peripheral (p) Tfh expressing T cell immunoreceptor with Ig and ITIM domains (TIGIT), expanded activated memory B cells and contracted CD11b+ monocytes. Draining lymph node (LN) tissue from IL-21 treated animals revealed direct association between LN follicle Tfh density and frequency of circulating TIGIT+ pTfh cells. We conclude that IL-21 enhances flu vaccine-induced Ab responses in SIV+ aged RM acting as an adjuvant modulating LN germinal center activity. Strategies to supplement IL-21 in aging could be a valuable addition in the toolbox for improving vaccine responses in an aging HIV+ population. |
| Databáze: | OpenAIRE |
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