Prion Protein Alleles Showing a Protective Effect on the Susceptibility of Sheep to Scrapie and Bovine Spongiform Encephalopathy
| Autor: | Claudia D'Agostino, L Morelli, Renata Borroni, Gabriele Vaccari, Luigi De Grossi, Michele Angelo Di Bari, Barbara Chiappini, Francesca Rosone, Romolo Nonno, Elena Esposito, Umberto Agrimi, Francesco Giordani, Stefano Marcon, Michela Conte |
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| Rok vydání: | 2007 |
| Předmět: |
Prions
animal diseases Bovine spongiform encephalopathy Molecular Sequence Data Immunology Scrapie Biology Polymorphism Single Nucleotide Microbiology Degenerative disease Virology medicine Animals Genetic Predisposition to Disease Base sequence Allele Prion protein Alleles Sheep Base Sequence Amino acid substitution Classical scrapie medicine.disease nervous system diseases Encephalopathy Bovine Spongiform Amino Acid Substitution Insect Science Pathogenesis and Immunity Cattle |
| Zdroj: | Journal of Virology. 81:7306-7309 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.02880-06 |
| Popis: | The susceptibility of sheep to classical scrapie and bovine spongiform encephalopathy (BSE) is mainly influenced by prion protein (PrP) polymorphisms A136V, R154H, and Q171R, with the ARR allele associated with significantly decreased susceptibility. Here we report the protective effect of the amino acid substitution M137T, I142K, or N176K on the ARQ allele in sheep experimentally challenged with either scrapie or BSE. Such observations suggest the existence of additional PrP alleles that significantly decrease the susceptibility of sheep to transmissible spongiform encephalopathies, which may have important implications for disease eradication strategies. |
| Databáze: | OpenAIRE |
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