Programmed Death Ligand 1: A Step Toward Immunoscore for Esophageal Cancer
| Autor: | Joeffrey J. Chahine, Conor F. Hynes, M. Blair Marshall, Nadim Haddad, Alexander Lofthus, Bhaskar Kallakury, Dong H. Kwon, Chaitanya Vadlamudi, Sameer Desale, Marc Margolis, Aya Iwamoto, Thomas J. Watson |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Pulmonary and Respiratory Medicine medicine.medical_specialty Time Factors Esophageal Neoplasms medicine.medical_treatment Context (language use) Adenocarcinoma Malignancy Gastroenterology B7-H1 Antigen 03 medical and health sciences Lymphocytes Tumor-Infiltrating 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans Lymphocyte Count Neoadjuvant therapy Aged Retrospective Studies Immunity Cellular Chemotherapy business.industry Perioperative Esophageal cancer Prognosis medicine.disease Immunohistochemistry Log-rank test Radiation therapy 030104 developmental biology 030220 oncology & carcinogenesis Female Surgery Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | The Annals of Thoracic Surgery. 106:1002-1007 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/j.athoracsur.2018.05.002 |
| Popis: | Background This study sought to evaluate the effect of tumor-infiltrating lymphocyte (TIL) density and programmed death ligand 1 (PD-L1) expression on the prognosis of esophageal cancer. Methods Banked tissue specimens from 53 patients who underwent esophagectomies for malignancy at a single institution over a 6-year period were stained for cluster of differentiation 3 (CD3), CD8, and PD-L1. Tumors were characterized as staining high or low density for CD3 and CD8, as well as positive or negative for PD-L1. TIL density and PD-L1 expression were analyzed in the context of survival, recurrence, and perioperative characteristics. Results Median follow-up was 823 days, with 92.5% survival and 26.8% recurrence rates. All tumors were adenocarcinomas. Neoadjuvant chemotherapy was given in 56.6% of cases, and neoadjuvant radiotherapy was given in 37.7%. High CD3 density was found in 83%, whereas high CD8 density was found in 56.6%. A total of 18.9% of the tumors stained positive for PD-L1. Survival was significantly shorter in Kaplan-Meier analysis for patients with primary tumors staining positive for PD-L1 (log rank: p = 0.05). Multivariable analysis controlling for neoadjuvant therapy, TIL markers, PD-L1, age, and sex found no significant difference in recurrence or survival. Conclusions Positive staining for PD-L1 may be a prognostic marker for decreased survival in esophageal adenocarcinoma. Additional TIL cell types should be investigated for creation of an esophageal cancer Immunoscore. PD-L1 has potential as a therapeutic target. |
| Databáze: | OpenAIRE |
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