Secretion of laminin alpha 2 chain in cerebrospinal fluid
| Autor: | Teruo Shimizu, Hiroki Yamada, Kiichiro Matsumura, Shuntaro Hojo, Hisae Hori, Sachiko Fujita, Hiroko Fukuta-Ohi, Takeshi Tanaka, Akira Tamura |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Peripheral dysmyelination
Congenital muscular dystrophy Immunoblotting Biophysics Biology Biochemistry Muscular Dystrophies Cerebrospinal fluid Structural Biology Genetics medicine Myocyte Animals Humans Secretion Molecular Biology chemistry.chemical_classification dy mouse Antibodies Monoclonal Cell Biology medicine.disease Molecular biology Immunohistochemistry medicine.anatomical_structure chemistry Immunology Laminin α2 chain Choroid Plexus Myelinogenesis Laminin-2 Choroid plexus Cattle Electrophoresis Polyacrylamide Gel Laminin Glycoprotein Spinal Nerve Roots |
| Zdroj: | FEBS letters. 376(1-2) |
| ISSN: | 0014-5793 |
| Popis: | The absence of laminin alpha 2 chain causes muscle cell degeneration and peripheral dysmyelination in congenital muscular dystrophy patients and dy mice, suggesting its role in the maintenance of sarcolemmal architecture and peripheral myelinogenesis. Here we demonstrate the secretion of laminin alpha 2 chain in cerebrospinal fluid (CSF). Laminin alpha 2 chain was detected as a minor component of the total CSF proteins or glycoproteins. Laminin alpha 2 chain was localized in the cytoplasm of epithelial cells of choroid plexus, suggesting active secretion. Our results suggest that immunochemical analysis of CSF laminin alpha 2 chain could be useful as an aid for the diagnosis of congenital muscular dystrophy. |
| Databáze: | OpenAIRE |
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