Trypanosoma brucei inhibition by essential oils from medicinal and aromatic plants traditionally uUsed in Cameroon (Azadirachta indica, Aframomum melegueta, Aframomum daniellii, Clausena anisata, Dichrostachys cinerea and Echinops giganteus)
| Autor: | Léon Azefack Ta, Anders Hofer, Hélène Mbuntcha, Loredana Cappellacci, Prosper Cabral Biapa Nya, Riccardo Petrelli, Stephane L. Ngahang Kamte, Luciano Barboni, Verlaine Woguem, Hilaire Macaire Womeni, Farahnaz Ranjbarian, Gustavo D. Campagnaro, Giovanni Benelli, Cristiano Giordani, Filippo Maggi |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
African trypanosomiases BALB 3T3 Cells Clausena anisata Health Toxicology and Mutagenesis Monoterpene Volatile lcsh:Medicine essential oils Trypanosma brucei Cameroon aromatic and medicinal plants 01 natural sciences Medicinal chemistry.chemical_compound Mice Aromatic and medicinal plants Aframomum melegueta biology Traditional medicine Essential oils Animals Humans Microbial Sensitivity Tests Monoterpenes Oils Volatile Plants Medicinal Sesquiterpenes Trypanosoma brucei brucei Magnoliopsida Public Health Global Health Social Medicine and Epidemiology Azadirachta Plants Dichrostachys cinerea Trypanosoma brucei Sesquiterpene Article 03 medical and health sciences Arbetsmedicin och miljömedicin food Botany Echinops lcsh:R Public Health Environmental and Occupational Health Occupational Health and Environmental Health biology.organism_classification food.food 0104 chemical sciences 010404 medicinal & biomolecular chemistry Folkhälsovetenskap global hälsa socialmedicin och epidemiologi 030104 developmental biology chemistry Oils |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 14, Iss 7, p 737 (2017) International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health; Volume 14; Issue 7; Pages: 737 |
| ISSN: | 1661-7827 |
| Popis: | Essential oils are complex mixtures of volatile components produced by the plant secondary metabolism and consist mainly of monoterpenes and sesquiterpenes and, to a minor extent, of aromatic and aliphatic compounds. They are exploited in several fields such as perfumery, food, pharmaceutics, and cosmetics. Essential oils have long-standing uses in the treatment of infectious diseases and parasitosis in humans and animals. In this regard, their therapeutic potential against human African trypanosomiasis (HAT) has not been fully explored. In the present work, we have selected six medicinal and aromatic plants (Azadirachta indica, Aframomum melegueta, Aframomum daniellii, Clausena anisata, Dichrostachys cinerea, and Echinops giganteus) traditionally used in Cameroon to treat several disorders, including infections and parasitic diseases, and evaluated the activity of their essential oils against Trypanosma brucei TC221. Their selectivity was also determined with Balb/3T3 (mouse embryonic fibroblast cell line) cells as a reference. The results showed that the essential oils from A. indica, A. daniellii, and E. giganteus were the most active ones, with half maximal inhibitory concentration (IC50) values of 15.21, 7.65, and 10.50 mu g/mL, respectively. These essential oils were characterized by different chemical compounds such as sesquiterpene hydrocarbons, monoterpene hydrocarbons, and oxygenated sesquiterpenes. Some of their main components were assayed as well on T. brucei TC221, and their effects were linked to those of essential oils. |
| Databáze: | OpenAIRE |
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