Enantioselective [2+2]-cycloadditions with triplet photoenzymes

Autor:	Ningning Sun, Jianjian Huang, Junyi Qian, Tai-Ping Zhou, Juan Guo, Langyu Tang, Wentao Zhang, Yaming Deng, Weining Zhao, Guojiao Wu, Rong-Zhen Liao, Xi Chen, Fangrui Zhong, Yuzhou Wu
Rok vydání:	2022
Předmět:	Indoles Multidisciplinary Cycloaddition Reaction Energy Transfer Biocatalysis Stereoisomerism Directed Molecular Evolution Photochemical Processes Crystallization Enzymes Substrate Specificity
Zdroj:	Nature. 611:715-720
ISSN:	1476-4687 0028-0836
DOI:	10.1038/s41586-022-05342-4
Popis:	Naturally evolved enzymes, despite their astonishingly large variety and functional diversity, operate predominantly through thermochemical activation. Integrating prominent photocatalysis modes into proteins, such as triplet energy transfer, could create artificial photoenzymes that expand the scope of natural biocatalysis
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2efb15de99240c589bb26445438e6527 https://doi.org/10.1038/s41586-022-05342-4 Zobrazit plný text záznamu Full text from SpringerLink