Endotoxin and particulate matter emitted by livestock farms and respiratory health effects in neighboring residents

Autor: de Rooij, Myrna M T, Smit, Lidwien A M, Erbrink, Hans J, Hagenaars, Thomas J, Hoek, Gerard, Ogink, Nico W M, Winkel, Albert, Heederik, Dick J J, Wouters, Inge M, One Health Microbieel, dIRAS RA-I&I RA, One Health Chemisch
Přispěvatelé: One Health Microbieel, dIRAS RA-I&I RA, One Health Chemisch
Rok vydání: 2019
Předmět:
Male
spatial modelling
endotoxin
Livestock associated
010504 meteorology & atmospheric sciences
Epidemiology
animal diseases
air pollution
Air pollution
010501 environmental sciences
medicine.disease_cause
01 natural sciences
Prevalence
lcsh:Environmental sciences
General Environmental Science
lcsh:GE1-350
Air Pollutants
education.field_of_study
public health
Particulates
Emissions
Female
Livestock
Emissions & Manure Valorisation
livestock farming
emmisions
medicine.medical_specialty
Farms
Bioinformatica & Diermodellen
Population
Emissie & Mestverwaarding
Health outcomes
Environmental health
Bio-informatics & Animal models
medicine
Animals
Humans
Epidemiology
Bio-informatics & Animal models
education
Respiratory health
0105 earth and related environmental sciences
Asthma
Epidemiologie
business.industry
Public health
Environmental Exposure
Respiration Disorders
medicine.disease
Endotoxins
Cross-Sectional Studies
Epidemiologie
Bioinformatica & Diermodellen
WIAS
Particulate Matter
business
Zdroj: Environment International, Vol 132, Iss, Pp-(2019)
Environment international, 132. Elsevier Limited
Environment International, 132
Environment International 132 (2019)
ISSN: 0160-4120
DOI: 10.1183/13993003.congress-2019.pa1980
Popis: Background: Living in livestock-dense areas has been associated with health effects, suggesting airborne exposures to livestock farm emissions to be relevant for public health. Livestock farm emissions involve complex mixtures of various gases and particles. Endotoxin, a pro-inflammatory agent of microbial origin, is a constituent of livestock farm emitted particulate matter (PM) that is potentially related to the observed health effects. Quantification of livestock associated endotoxin exposure at residential addresses in relation to health outcomes has not been performed earlier. Objectives: We aimed to assess exposure-response relations for a range of respiratory endpoints and atopic sensitization in relation to livestock farm associated PM10 and endotoxin levels. Methods: Self-reported respiratory symptoms of 12,117 persons participating in a population-based cross-sectional study were analyzed. For 2494 persons, data on lung function (spirometry) and serologically assessed atopic sensitization was additionally available. Annual-average PM10 and endotoxin concentrations at home addresses were predicted by dispersion modelling and land-use regression (LUR) modelling. Exposure-response relations were analyzed with generalized additive models. Results: Health outcomes were generally more strongly associated with exposure to livestock farm emitted endotoxin compared to PM10. An inverse association was observed for dispersion modelled exposure with atopic sensitization (endotoxin: p = .004, PM10: p = .07) and asthma (endotoxin: p = .029, PM10: p = .022). Prevalence of respiratory symptoms decreased with increasing endotoxin concentration at the lower range, while at the higher range prevalence increased with increasing concentration (p .05). Conclusions: Exposure to livestock farm emitted particulate matter is associated with respiratory health effects and atopic sensitization in non-farming residents. Results indicate endotoxin to be a potentially plausible etiologic agent, suggesting non-infectious aspects of microbial emissions from livestock farms to be important with respect to public health. Keywords: Livestock farming, Emissions, Air pollution, Public health, Spatial modelling, Endotoxin
Databáze: OpenAIRE
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