Changes in behavioral and neuronal parameters by alcohol, cigarette, or their combined use in rats
| Autor: | Alana Witt Hansen, Heloísa Deola Confortim, Clara Lindenmayer Della Giustina, Bruna Ferrary Deniz, Lenir Orlandi Pereira Silva, Greice Caletti, Rosane Gomez, Rianne Remus Pulcinelli, Solange Bandiera, Maurício Schüler Nin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Nicotine Combined use Alcohol Hippocampus Oral gavage Open field 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Administration Inhalation medicine Cigarette smoke Hippocampus (mythology) Animals Rats Wistar Pharmacology Neurons Inhalation Behavior Animal Ethanol business.industry Smoking Tobacco Products 030227 psychiatry Rats Psychiatry and Mental health Endocrinology medicine.anatomical_structure chemistry Neuron business 030217 neurology & neurosurgery |
| Zdroj: | Behavioural pharmacology. 30(6) |
| ISSN: | 1473-5849 |
| Popis: | Few studies have explored the effects of the combined use of alcohol and cigarette in humans, despite its prevalence. Here we evaluated the effect of isolated and combined use on behaviors and neuronal parameters in rats. Male adult rats were divided into alcohol (AL, 2 g/kg, by oral gavage), cigarette smoke (TB, six cigarettes, by inhalation), combined use (ALTB), or control (CT, water by oral gavage and environmental air) groups, treated twice a day (09.00 and 14.00 h). After 4 weeks, the rats were tested in the open field for behavioral analysis and euthanized for brain volume estimation and counting of neurons in the hippocampus. All treatments increased locomotion, and this behavior was higher in the ALTB than TB group. Latency to exit from the central area was lower in the ALTB than in the AL or CT groups. Rearing behavior increased in TB and decreased in AL and ALTB rats. Combined ALTB rats significantly increased their grooming behavior. Only the AL group showed decreased neuron counts and increased brain volume. Our results show that the isolated and combined uses of alcohol and cigarette smoke have diverse effects on behavioral and neuronal parameters in rats after long-term treatment. |
| Databáze: | OpenAIRE |
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