Prevalence of RhD variants among blood donors at Gulu Regional Blood Bank, Gulu, Northern Uganda
| Autor: | Fred Webbo, Polycarp Ojok, Caesar Oyet, Ivan Mugisha Taremwa, Bashir Mwambi |
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| Rok vydání: | 2017 |
| Předmět: |
weak D
medicine.medical_specialty Hemagglutination 030204 cardiovascular system & hematology Journal of Blood Medicine 03 medical and health sciences 0302 clinical medicine Rh blood group Internal medicine ABO blood group system medicine Uganda Typing Original Research partial D D variants IgG.monoclonal business.industry D antigen Hematology Confidence interval Immunology RhD negative business Rh blood group system Blood bank 030215 immunology |
| Zdroj: | Journal of Blood Medicine |
| ISSN: | 1179-2736 |
| DOI: | 10.2147/jbm.s145550 |
| Popis: | Aim/objective The aim of this study was to determine the prevalence of RhD variant phenotypes among voluntary non-remunerated blood donors (VNRBDs) at Gulu Regional Blood Bank (GRBB), Northern Uganda. Materials and methods We conducted a cross-sectional study, in which the first 4.0 mL of ethylenediaminetetraacetic acid (EDTA) blood samples were collected from VNRBDs and typed for their ABO and RhD blood group status using IgM and IgG monoclonal typing antisera, respectively. Blood samples that tested as RhD negative were further investigated for RhD variant phenotypes using indirect antihuman globulin hemagglutination technique. Results We assayed 138 RhD-negative blood samples obtained from VNRBDs. Of these, 66.7% (n=92) were males. Their median age was 24.4 years (range, 14–33 years). Majority of the participants were of ABO blood group O (62.8%, n=86), followed by A (19.7%, n=27), then B (13.9%, n=19) and least AB (3.6%, n=6). The prevalence of RhD variant phenotypes was 0.7% (n=1; 95% confidence interval, 0.5–0.9). There was no statistical association of RhD variant phenotypes with donor gender, tribe and their ABO blood groups. Conclusion This study has revealed a high prevalence of RhD variant among blood donors at GRBB in Northern Uganda. It further highlights a potential risk of alloimmunization, as the present blood typing practices do not identify RhD variant phenotypes. Video abstract |
| Databáze: | OpenAIRE |
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