Fatty acid receptor GPR120: a novel marker for human melanoma
| Autor: | Johannes Kleemann, Stefan Kippenberger, Jan Ter-Nedden, Roland Kaufmann, Pia Kleimann, Igor Hrgovic, Katja Steinhorst, Katja Härle, Jutta Müller, Markus Meissner |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Cancer Research Skin Neoplasms Dermatology Receptors G-Protein-Coupled Pathogenesis 03 medical and health sciences medicine Humans Receptor Melanoma Ultraviolet radiation Retrospective Studies chemistry.chemical_classification business.industry Fatty acid GPR120 Middle Aged medicine.disease Immunohistochemistry 030104 developmental biology Oncology chemistry Cancer research Female Human melanoma Epidemiologic data business |
| Zdroj: | Melanoma Research. 28:271-276 |
| ISSN: | 0960-8931 |
| DOI: | 10.1097/cmr.0000000000000445 |
| Popis: | The correlation between ultraviolet radiation of the skin and melanoma incidence in humans is well established. Interestingly, epidemiologic data suggest also a correlation to an increased BMI pointing to metabolic trigger factors in melanoma pathogenesis. To substantiate this connection, we studied the expression of G-protein-coupled receptor 120 (GPR120), a receptor sensitive to unsaturated long-chain free fatty acids in melanoma tissues. One-hundred fourteen tissue sections histologically confirmed as nevi (n=32), primary melanoma (n=39), and melanoma metastasis (n=43) were immunohistochemically stained against GPR120. The staining was evaluated by three trained dermatopathologists and independently scored. Compared with nevi, primary melanoma and melanoma metastasis showed significantly higher levels of GPR120 staining. Only three out of 32 nevi showed strong GPR120 expression [median immunoreactivity-scoring system (IRS) score: 1, range: 0-10], whereas in primary melanomas 14 out of 39 were highly GPR120-positive (median IRS score: 7, range: 0-12) and in melanoma metastasis 27 out of 43 were highly GPR120-positive (median IRS score: 9, range: 0-12). GPR120 expression and tumor thickness (mm) show a statistically significant correlation in primary melanoma (P=0.011). Moreover, GPR120-positive staining was found throughout the epidermis and in sebaceous and sweat glands, which is yet not described. This study identified GPR120 as a novel marker for melanoma, indicating that melanoma cells are sensitive to free fatty acids. It is tempting to speculate that pharmacologically interfering with GPR120 signaling might improve melanoma therapy. |
| Databáze: | OpenAIRE |
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