Antigenic specificity of antibodies from patients with linear basement membrane deposition of IgA
| Autor: | January Smith, E. Pazderka Smith, Laurence Meyer, Douglas L. Powell, John J. Zone, Ted B. Taylor |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Immunoglobulin A
Adult Pemphigoid Blotting Western Pemphigoid Benign Mucous Membrane Fluorescent Antibody Technique Dermatology Epitope Immunoglobulin G Basement Membrane Epitopes Antigen medicine Humans Cicatricial pemphigoid Child Skin Basement membrane integumentary system biology Skin Diseases Vesiculobullous Chemistry medicine.disease medicine.anatomical_structure Immunology biology.protein Antibody |
| Zdroj: | Dermatology (Basel, Switzerland). 189 |
| ISSN: | 1018-8665 |
| Popis: | We reviewed the immunoreactivity of sera binding to the epidermal side of basement membrane split skin from 13 adults and 8 children with IgA alone, 9 adults with IgA and IgG and 7 adults with IgA and ocular pemphigoid. Immunoblots were done against previously described 45-, 97-, 180- and 230-kD antigens, and reactivity was confirmed by elution of antibody from nitrocellulose and binding to the basement membrane. Ten of 13 adults and 7 of 8 children reacted with the 97-kD antigen. Sera with both IgA and IgG reacted in varying patterns and on occasion with more than 1 antigen. All 7 patients with ocular cicatricial pemphigoid reacted uniquely with a 45-kD antigen. |
| Databáze: | OpenAIRE |
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