Rituximab for the therapy of systemic sclerosis: a series of 10 cases in a single center
| Autor: | Lívia Marques da Silva Gama, Giselle Baptista Maretti, Verônica Silva Vilela, Cláudia Henrique da Costa, Roger A. Levy, Rogério Rufino |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
lcsh:Diseases of the musculoskeletal system Cyclophosphamide Disease Single Center Pulmonary fibrosis 03 medical and health sciences 0302 clinical medicine Refractory Internal medicine medicine Esclerose sistêmica Humans Immunologic Factors 030212 general & internal medicine Lung General Environmental Science Retrospective Studies 030203 arthritis & rheumatology Autoimmune disease B-Lymphocytes Scleroderma Systemic business.industry Modified Rodnan skin score Medical record medicine.disease Surgery Fibrose pulmonar Treatment Outcome General Earth and Planetary Sciences Systemic sclerosis Rituximab lcsh:RC925-935 business Rituximabe Progressive disease Escore cutâneo modificado de Rodnan medicine.drug |
| Zdroj: | Revista Brasileira de Reumatologia, Vol 56, Iss 5, Pp 458-463 |
| ISSN: | 1809-4570 |
| Popis: | Systemic sclerosis (SSc) is a chronic autoimmune disease with a high morbidity and mortality. Although cyclophosphamide is effective for severe and refractory cases, there is demand for new treatments. The biological treatment with B-cell depletion with rituximab (RTX) has demonstrated efficacy for this demand in open-label studies. Objective This study was conducted with the aim to retrospectively evaluate all patients who used RTX for the treatment of SSc in our center. Patients and methods We retrospectively evaluated medical records of all patients with SSc who used RTX to treat this disease from January 2009 to January 2015. Systemic, cutaneous, and pulmonary involvement data and laboratory results before and six months after the first infusion of RTX were collected. Results Ten patients received treatment during the study period and were included in this series. All patients had a diffuse form of the disease. Five patients suffered from an early (duration of disease shorter or equal to four years), rapidly progressive disease, and another five received RTX at late stages of the disease. In both groups of patients, stabilization of the pulmonary picture was observed, with a fall in the skin score in those patients with early forms of the disease. Discussion Similar to findings in previous studies, RTX was effective in treating early and rapidly progressive forms of SSc. We also found that patients with long-term illness may benefit from the treatment. |
| Databáze: | OpenAIRE |
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