Visible Light Photochemical Reactions for Nucleic Acid-Based Technologies
| Autor: | Ho Jeong Choi, Haneul Yoo, Bonwoo Koo, Cheoljae Kim, Ki Tae Kim, Min Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Light
templated reaction nucleic acid-based technologies Chemical biology Pharmaceutical Science Review Photochemistry Chemical reaction Catalysis Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Functional importance lcsh:Organic chemistry Drug Discovery Molecule Physical and Theoretical Chemistry visible light Fluorescent Dyes Reaction conditions photochemical reactions Chemistry Organic Chemistry DNA Photochemical Processes nucleic acids Chemistry (miscellaneous) Nucleic acid Molecular Medicine Visible spectrum |
| Zdroj: | Molecules, Vol 26, Iss 556, p 556 (2021) Molecules |
| ISSN: | 1420-3049 |
| Popis: | The expanding scope of chemical reactions applied to nucleic acids has diversified the design of nucleic acid-based technologies that are essential to medicinal chemistry and chemical biology. Among chemical reactions, visible light photochemical reaction is considered a promising tool that can be used for the manipulations of nucleic acids owing to its advantages, such as mild reaction conditions and ease of the reaction process. Of late, inspired by the development of visible light-absorbing molecules and photocatalysts, visible light-driven photochemical reactions have been used to conduct various molecular manipulations, such as the cleavage or ligation of nucleic acids and other molecules as well as the synthesis of functional molecules. In this review, we describe the recent developments (from 2010) in visible light photochemical reactions involving nucleic acids and their applications in the design of nucleic acid-based technologies including DNA photocleaving, DNA photoligation, nucleic acid sensors, the release of functional molecules, and DNA-encoded libraries. |
| Databáze: | OpenAIRE |
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