Effect of Aminated Chitosan-Coated Fe3O4 Nanoparticles with Applicational Potential in Nanomedicine on DPPG, DSPC, and POPC Langmuir Monolayers as Cell Membrane Models
| Autor: | Emilia Piosik, Marta Ziegler-Borowska, Tomasz Martyński, Dorota Chełminiak-Dudkiewicz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Langmuir
Langmuir film Nanoparticle 02 engineering and technology 010402 general chemistry 01 natural sciences Catalysis lcsh:Chemistry Inorganic Chemistry chemistry.chemical_compound Adsorption Monolayer Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology POPC Spectroscopy Alkyl chemistry.chemical_classification aminated chitosan Organic Chemistry technology industry and agriculture General Medicine 021001 nanoscience & nanotechnology nanomedicine 0104 chemical sciences Computer Science Applications magnetite nanoparticles Membrane lcsh:Biology (General) lcsh:QD1-999 Chemical engineering chemistry Nanomedicine lipids (amino acids peptides and proteins) 0210 nano-technology cell membrane |
| Zdroj: | International Journal of Molecular Sciences Volume 22 Issue 5 International Journal of Molecular Sciences, Vol 22, Iss 2467, p 2467 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22052467 |
| Popis: | An adsorption process of magnetite nanoparticles functionalized with aminated chitosan (Fe3O4-AChit) showing application potential in nanomedicine into cell membrane models was studied. The cell membrane models were formed using a Langmuir technique from three selected phospholipids with different polar head-groups as well as length and carbon saturation of alkyl chains. The research presented in this work reveals the existence of membrane model composition-dependent regulation of phospholipid-nanoparticle interactions. The influence of the positively charged Fe3O4-AChit nanoparticles on a Langmuir film stability, phase state, and textures is much greater in the case of these formed by negatively charged 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DPPG) than those created by zwitterionic 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and 2-oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine (POPC). The adsorption kinetics recorded during penetration experiments show that this effect is caused by the strongest adsorption of the investigated nanoparticles into the DPPG monolayer driven very likely by the electrostatic attraction. The differences in the adsorption strength of the Fe3O4-AChit nanoparticles into the Langmuir films formed by the phosphatidylcholines were also observed. The nanoparticles adsorbed more easily into more loosely packed POPC monolayer. |
| Databáze: | OpenAIRE |
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