Quantitative description of whole blood CO2 dissociation curve and Haldane effect
| Autor: | Jack A. Loeppky, E.R. Fletcher, Ulrich C. Luft |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Physiology Chemistry Partial Pressure Analytical chemistry Oxygen–haemoglobin dissociation curve Oxygenation Carbon Dioxide Models Biological Absorption Surgery Oxygen Hemoglobins Haldane effect In vivo medicine Humans Hemoglobin Mixed venous blood Saturation (chemistry) Whole blood |
| Zdroj: | Respiration Physiology. 51:167-181 |
| ISSN: | 0034-5687 |
| DOI: | 10.1016/0034-5687(83)90038-5 |
| Popis: | A simple procedure is presented to describe accurately the whole blood CO 2 dissociation curve on linear content (C CO 2 ) and pressure (P CO 2 ) coordinates with an exponential equation (C CO 2 = K·P CO 2 b ). A single coordinated and the hemoglobin concentration, Hb, are required. Whole blood C CO 2 can be calculated from values for pH, P CO 2 , Hb and O 2 saturation by empirically accurate equations. The mathematical description of the CO 2 curve was employed to quantitate the in vivo Haldane factor (f H ) from simultaneous arterial and mixed venous blood samples in 20 healthy exercising subjects. The mean ± SE was 0.28 ± 0.03 (vol. % ΔC CO 2 /vol. % δHbO 2 ). In 20 patients with severe obstructive lung disease f H was 0.29 ± 0.08 when calculated from arterial samples while breathing air and 100% O 2 . Values for f H were not related significantly to acid-base status or Hb as suggested by previous workers. By assuming these or other values for f H , the in vivo change in blood P CO 2 resulting from a given change in oxygenation can be predicted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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