Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer
| Autor: | Pavel Vodicka, Alessio Naccarati, Barbara Pardini, Veronika Vymetalkova |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Colorectal cancer SNP Genome-wide association study Disease Biology 03 medical and health sciences 0302 clinical medicine microRNA medicine Epigenetics Polymorphism Genetic association Genetics miRNA target site Non-coding RNA medicine.disease miRSNP digestive system diseases 030104 developmental biology Risk factors 030220 oncology & carcinogenesis Cancer research |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9783319420578 |
| Popis: | Colorectal cancer (CRC) is a complex disease that develops as a consequence of both genetic and environmental risk factors in interplay with epigenetic mechanisms, such as microRNAs (miRNAs). CRC cases are predominantly sporadic in which the disease develops with no apparent hereditary syndrome. The last decade has seen the progress of genome-wide association studies (GWAS) that allowed the discovery of several genetic regions and variants associated with weak effects on sporadic CRC. Collectively these variants may enable a more accurate prediction of an individual’s risk to the disease and its prognosis. However, the number of variants contributing to CRC is still not fully explored. |
| Databáze: | OpenAIRE |
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