Diffusion of Particles in the Extracellular Matrix: The Effect of Repulsive Electrostatic Interactions
| Autor: | Stylianopoulos, T., Poh, M. Z., Insin, N., Bawendi, M. G., Fukumura, D., Munn, L. L., Jain, R. K. |
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| Přispěvatelé: | Stylianopoulos, T. [0000-0002-3093-1696] |
| Jazyk: | angličtina |
| Předmět: |
Models
Molecular Quantitative Biology::Tissues and Organs Static Electricity Physics::Medical Physics Analytical chemistry Biophysics Nanoparticle 02 engineering and technology 010402 general chemistry 01 natural sciences Models Biological Diffusion symbols.namesake Drug Delivery Systems Neoplasms Static electricity Animals Diffusion (business) Particle Size Debye length Chemistry Osmolar Concentration Reproducibility of Results 021001 nanoscience & nanotechnology Electrostatics Charged particle Biological Systems and Multicellular Dynamics 0104 chemical sciences Extracellular Matrix Rats Chemical physics symbols Hydrodynamics Particle Nanoparticles Particle size Collagen 0210 nano-technology |
| Zdroj: | Biophysical journal |
| ISSN: | 0006-3495 |
| DOI: | 10.1016/j.bpj.2010.06.016 |
| Popis: | Diffusive transport of macromolecules and nanoparticles in charged fibrous media is of interest in many biological applications, including drug delivery and separation processes. Experimental findings have shown that diffusion can be significantly hindered by electrostatic interactions between the diffusing particle and charged components of the extracellular matrix. The implications, however, have not been analyzed rigorously. Here, we present a mathematical framework to study the effect of charge on the diffusive transport of macromolecules and nanoparticles in the extracellular matrix of biological tissues. The model takes into account steric, hydrodynamic, and electrostatic interactions. We show that when the fiber size is comparable to the Debye length, electrostatic forces between the fibers and the particles result in slowed diffusion. However, as the fiber diameter increases the repulsive forces become less important. Our results explain the experimental observations that neutral particles diffuse faster than charged particles. Taken together, we conclude that optimal particles for delivery to tumors should be initially cationic to target the tumor vessels and then change to neutral charge after exiting the blood vessels. © 2010 by the Biophysical Society. 99 1342 1349 1342-1349 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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