Tumorablative conditioning regimen for haploidentical stem cell transplantation in 102 children with hematologic malignancies: a single-center experience
| Autor: | Luo Rongmu, Wang Ya, Da Wanming, Si Yingjian, Zhang Xiaomei, Gu Wenjing, Chen Wei, Wang Yang, Du Zhenlan, Xing Guosheng |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Disease Hematopoietic stem cell transplantation Single Center 03 medical and health sciences 0302 clinical medicine conditioning Internal medicine medicine graft-versus-host disease Cumulative incidence Hematology business.industry haploidentical medicine.disease Transplantation Regimen Graft-versus-host disease surgical procedures operative Oncology 030220 oncology & carcinogenesis hematopoietic stem cell transplantation hematologic malignancy business 030215 immunology Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Luo Rongmu 1, 2, 3 , Zhang Xiaomei 1, 2, 3 , Du Zhenlan 1, 2, 3 , Wang Ya 1, 2, 3 , Chen Wei 1, 2, 3 , Si Yingjian 1, 2, 3 , Gu Wenjing 1, 2, 3 , Xing Guosheng 1, 2, 3 , Wang Yang 1, 2, 3 and Da Wanming 1, 4 1 Affiliated BaYi Children’s Hospital, PLA Army General Hospital, Beijing, China 2 National Engineering Laboratory for Birth Defects Prevention and Control of Key Technology, Beijing, China 3 Beijing Key Laboratory of Pediatric Organ Failure, Beijing, China 4 Department of Hematology, Chinese PLA General Hospital, Beijing, China Correspondence to: Da Wanming, email: Dwanming@medmail.com.cn Luo Rongmu, email: luorongmu@163.com Keywords: conditioning; haploidentical; hematopoietic stem cell transplantation; hematologic malignancy; graft-versus-host disease Received: August 21, 2017 Accepted: November 13, 2017 Published: December 04, 2017 ABSTRACT Haploidentical hematopoietic stem cell transplantation (Haplo-HSCT) is widely carried out in China, and transplantation related complications decreased gradually with the transplant technology improving, and the overall survival(OS) increased year by year. However, relapse after transplantation is still one of the main causes of death in patients with hematological malignancy. In order to reduce the recurrence after HSCT, we set a tumorablative conditioning regimen (TAC ) regimen; the aim is as much as possible to eliminate the malignant clone to reduce the recurrence without increasing the conditioning toxicity. We retrospectively analyzed 102 cases of haplo-HSCT in our hospital from 2012 to 2017. Ninety-eight out of the 99 (99.0%) patients achieved primary engraftment. The 2-year OS and disease free survival (DFS) are 81.4% (83/102) and 77.45% (79/102). The cumulative incidence of leukemia relapse is 16.2% (16/99), Twenty-nine patients developed II-IV acute graft-versus-host disease (aGVHD) (29%) within 100 days and only nine patients have grade III-IV aGVHD (9%) in measurable 99 patients. The conditioning regimen was relatively well tolerated with limited regimen-related toxicity. The preliminary results show that TAC is safe and effective in haplo-HSCT of children with hematologic malignancies. This study will provide a clinical basis for the individualized conditioning regimen. |
| Databáze: | OpenAIRE |
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