Condylomata acuminata and risk of cancer: an epidemiological study
| Autor: | B Lindelof, Bardur Sigurgeirsson, Gunnar Eklund |
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| Předmět: |
Adult
Male medicine.medical_specialty Letter Uterine Cervical Neoplasms Cohort Studies Risk Factors Internal medicine Epidemiology medicine Humans Prospective Studies Risk factor Prospective cohort study General Environmental Science Gynecology Sweden Genitourinary system business.industry Incidence (epidemiology) Carcinoma in situ General Engineering Age Factors Obstetrics and Gynecology Cancer General Medicine medicine.disease Cancer registry Condylomata Acuminata Relative risk Cohort General Earth and Planetary Sciences Female business Carcinoma in Situ Urogenital Neoplasms Research Article Cohort study |
| Zdroj: | Europe PubMed Central |
| Popis: | OBJECTIVE--To determine whether patients with condylomata acuminata have an increased risk of developing cancer. DESIGN--Prospective cohort study on patients diagnosed as having condylomata acuminata. The number of malignant tumours in the cohort was compared with national incidences obtained from the Swedish Cancer Registry. SETTING--Dermatology department of the Karolinska Hospital, Stockholm, Sweden. SUBJECTS--3260 patients (2549 males and 711 females, median (range) age 23 (1-80) years) seen during 1969-84, with a mean follow up of 7.8 years. MAIN OUTCOME MEASURES--Number of malignant tumours observed in the cohort during the study period and expected number from national incidence. RESULTS--There were 27 malignancies in the study group. There was no significant increase genital cancer in females compared with the national incidence. Only one patient had invasive cervical cancer (relative risk = 1.8; 95% confidence interval 0 to 10.1). Seventeen women had cervical carcinoma in situ (1.5; 0.9 to 2.5) compared with an expected number of 11.5; this increase was not significant. For males 22 cancers were observed at all sites (1.6; 1.0 to 2.5). The number of genitourinary cancers observed in males was almost three times higher than expected (2.6; 1.2 to 5.0). CONCLUSION--The results indicate that the risk of developing cervical carcinoma in situ or invasive cervical cancer after a genital human papillomavirus infection is less than previously thought. The implications of increase in the genitourinary malignancies in males are uncertain. |
| Databáze: | OpenAIRE |
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