Usefulness of positron emission tomographic studies for gliomas
| Autor: | Takashi Tamiya, Masaki Okada, Keisuke Miyake, Daisuke Ogawa, Tetsuhiro Hatakeyama |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty [18F]fluoromisonidazole ([18F]FMISO) medicine.medical_treatment Tumor resection Brain tumor 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) Review Article Positron emission tomographic 03 medical and health sciences 0302 clinical medicine glioma medicine Humans positron emission tomography (PET) Chemotherapy medicine.diagnostic_test Brain Neoplasms business.industry Hypoxia (medical) medicine.disease Radiation therapy l-methyl-[11C]methionine ([11C]MET) Positron emission tomography Positron-Emission Tomography 030220 oncology & carcinogenesis Surgery Neurology (clinical) medicine.symptom Differential diagnosis business 030217 neurology & neurosurgery |
| Zdroj: | Neurologia medico-chirurgica |
| ISSN: | 1349-8029 0470-8105 |
| Popis: | Non-invasive positron emission tomography (PET) enables the measurement of metabolic and molecular processes with high sensitivity. PET plays a significant role in the diagnosis, prognosis, and treatment of brain tumors and predominantly detects brain tumors by detecting their metabolic alterations, including energy metabolism, amino acids, nucleic acids, and hypoxia. Glucose metabolic tracers are related to tumor cell energy and exhibit good sensitivity but poor specificity for malignant tumors. Amino acid metabolic tracers provide a better delineation of tumors and cellular proliferation. Nucleic acid metabolic tracers have a high sensitivity for malignant tumors and cellular proliferation. Hypoxic metabolism tracers are useful for detecting resistance to radiotherapy and chemotherapy. Therefore, PET imaging techniques are useful for detecting biopsy-targeting points, deciding on tumor resection, radiotherapy planning, monitoring therapy, and distinguishing brain tumor recurrence or progression from post-radiotherapy effects. However, it is not possible to use only one PET tracer to make all clinical decisions because each tracer has both advantages and disadvantages. This study focuses on the different kinds of PET tracers and summarizes their recent applications in patients with gliomas. Combinational uses of PET tracers are expected to contribute to differential diagnosis, prognosis, treatment targeting, and monitoring therapy. |
| Databáze: | OpenAIRE |
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