CarbMetSim: A discrete-event simulator for carbohydrate metabolism in humans

Autor: Husam Ghazaleh, Sanjay Rajasekharan, Buket Aydas, Mukul Goyal
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Metabolic Processes
Glycogens
Physiology
medicine.medical_treatment
Glycobiology
Adipose tissue
030204 cardiovascular system & hematology
Biochemistry
0302 clinical medicine
Endocrinology
Glucose Metabolism
Medicine and Health Sciences
Insulin
Glycolysis
Public and Occupational Health
Meals
Multidisciplinary
Organic Compounds
Monosaccharides
Sports Science
Body Fluids
Chemistry
Blood
Organ Specificity
Physical Sciences
Medicine
Carbohydrate Metabolism
Anatomy
Research Article
Science
Carbohydrates
030209 endocrinology & metabolism
Biology
Carbohydrate metabolism
Models
Biological
03 medical and health sciences
Insulin resistance
Diabetes mellitus
medicine
Humans
Computer Simulation
Sports and Exercise Medicine
Exercise
Simulation
Diabetic Endocrinology
Organic Chemistry
Chemical Compounds
Reproducibility of Results
Biology and Life Sciences
Lipid metabolism
Physical Activity
medicine.disease
Hormones
Gastrointestinal Tract
Glucose
Metabolism
Gluconeogenesis
Physical Fitness
Flux (metabolism)
Digestive System
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0209725 (2020)
DOI: 10.1101/491019
Popis: This paper describesCarbMetSim, adiscrete-eventsimulator that tracks the blood glucose level of a person in response to a timed sequence of diet and exercise activities.CarbMetSimimplements broader aspects of carbohydrate metabolism in human beings with the objective of capturing the average impact of various diet/exercise activities on the blood glucose level. Key organs (stomach, intestine, portal vein, liver, kidney, muscles, adipose tissue, brain and heart) are implemented to the extent necessary to capture their impact on the production and consumption of glucose. Key metabolic pathways (glucose oxidation, glycolysisandgluconeogenesis) are accounted for in the operation of different organs. The impact of insulin and insulin resistance on the operation of various organs and pathways is captured in accordance with published research.CarbMetSimprovides broad flexibility to configure the insulin production ability, the average flux along various metabolic pathways and the impact of insulin resistance on different aspects of carbohydrate metabolism. The simulator does not yet have a detailed implementation of protein and lipid metabolism.
Databáze: OpenAIRE
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