A comparative study of toluidine blue-mediated photodynamic therapy versus topical corticosteroids in the treatment of erosive-atrophic oral lichen planus: a randomized clinical controlled trial
| Autor: | Hooman Shafaee, Farnaz Falaki, Farzaneh Ahrari, Meysam Ahmadzadeh, Majid Sanatkhani, Hasan Hoseinpour Jajarm |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Administration Topical Mouthwashes Photodynamic therapy Dermatology Gastroenterology Dexamethasone law.invention chemistry.chemical_compound stomatognathic system Randomized controlled trial law Adrenal Cortex Hormones Internal medicine medicine Humans Toluidine Tolonium Chloride business.industry Significant difference Atrophic oral lichen planus Middle Aged medicine.disease Surgery Nystatin chemistry Photochemotherapy Oral lichen planus Female Lasers Semiconductor business medicine.drug Lichen Planus Oral |
| Zdroj: | Lasers in medical science. 30(5) |
| ISSN: | 1435-604X |
| Popis: | Recently, photodynamic therapy (PDT) has been suggested as a new treatment option that is free from side effects for erosive-atrophic oral lichen planus (OLP). The purpose of this study was to compare the effect of toluidine blue-mediated photodynamic therapy (TB-PDT) with local corticosteroids on treatment of erosive-atrophic OLP. In this randomized clinical trial, 25 patients with keratotic-atrophic-erosive oral lichen planus were allocated randomly into two groups. Group 1 (experimental): topical application of toluidine blue with micropipette was applied, and after 10 min, the patients were treated with a 630-nm GaAlAs laser (power density: 10 mW/cm(2)) during two visits. Group 2 (control) used mouthwash diluted with dexamethasone (tab 0/5 in 5 ml water) for 5 min, and then, it was spat out, and after 30 min, the mouth was rinsed with 30 drops of nystatin 100,000 units for 5 min and again spat out. Demographic data, type, and severity of the lesions and pain were recorded before and after treatment and then at the 1-month follow-up visit. Response rate was defined based on changes in intensity of the lesions and pain. In the experimental and control groups, sign scores of changes significantly reduced after treatment respectively (p = 0.021) and (p = 0.002), but between the two groups, no significant difference was observed (p = 0.72). In the experimental (p = 0.005) and control groups (p = 0.001), the intensity of lesions significantly reduced after treatment and there was a significant difference between the two groups (p = 0.001). The mean amount of improvement in pain was significantly greater in the control group compared with the experimental group (p 0.001) (α = 0.05). Our study showed that TB-PDT with laser was effective in the management of OLP. |
| Databáze: | OpenAIRE |
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