Results of the BRD CAP project: progress toward identifying genetic markers associated with BRD susceptibility
| Autor: | Jessica M. Davis, Andrzej J. Wojtowicz, Jeremy F. Taylor, Robert D. Schnabel, Holly L. Neibergs, Erik Chavez, Christopher M. Seabury, Terry W. Lehenbauer, Paul V. Rossitto, Jared E. Decker, James E. Womack, Beate Crossley, Robert Hagevoort, Erik Scraggs, J. Shannon Neibergs, Zeping Wang, Alison L. Van Eenennaam, Sharif S. Aly, Patricia C Blanchard |
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| Rok vydání: | 2014 |
| Předmět: |
Genetic Markers
Genetics Bovine Respiratory Disease Complex Chromosome Mapping Bovine respiratory disease Agriculture Genomics Single-nucleotide polymorphism Genome-wide association study Heritability Beef cattle Biology medicine.disease Polymorphism Single Nucleotide Genetic marker medicine Animals SNP Cattle Genetic Predisposition to Disease Animal Science and Zoology Animal Husbandry Genome-Wide Association Study |
| Zdroj: | Animal Health Research Reviews. 15:157-160 |
| ISSN: | 1475-2654 1466-2523 |
| DOI: | 10.1017/s1466252314000231 |
| Popis: | The Bovine Respiratory Disease Coordinated Agricultural Project (BRD CAP) is a 5-year project funded by the United States Department of Agriculture (USDA), with an overriding objective to use the tools of modern genomics to identify cattle that are less susceptible to BRD. To do this, two large genome wide association studies (GWAS) were conducted using a case:control design on preweaned Holstein dairy heifers and beef feedlot cattle. A health scoring system was used to identify BRD cases and controls. Heritability estimates for BRD susceptibility ranged from 19 to 21% in dairy calves to 29.2% in beef cattle when using numerical scores as a semi-quantitative definition of BRD. A GWAS analysis conducted on the dairy calf data showed that single nucleotide polymorphism (SNP) effects explained 20% of the variation in BRD incidence and 17–20% of the variation in clinical signs. These results represent a preliminary analysis of ongoing work to identify loci associated with BRD. Future work includes validation of the chromosomal regions and SNPs that have been identified as important for BRD susceptibility, fine mapping of chromosomes to identify causal SNPs, and integration of predictive markers for BRD susceptibility into genetic tests and national cattle genetic evaluations. |
| Databáze: | OpenAIRE |
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