Analysis of cross-reactive antigen-specific T cell clones. Specific recognition of two major histocompatibility complex (MHC) and two non- MHC antigens by a single clone
| Autor: | A. Ben-Nun, Martin E. Dorf, Steven J. Burakoff, Z Lando |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1983 |
| Předmět: |
Isoantigens
T cell T-Lymphocytes Immunology Priming (immunology) Major histocompatibility complex Epitope Cell Line Epitopes Mice Antigen Histocompatibility Antigens medicine Immunology and Allergy Animals Antigens Pan-T antigens Antigens Viral Mice Inbred BALB C biology Histocompatibility Antigens Class II Myelin Basic Protein Articles MHC restriction Virology Histocompatibility Clone Cells Rats medicine.anatomical_structure Influenza A virus Mice Inbred DBA biology.protein |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Two T cell clones, one specific for I-Es/d plus myelin basic protein (BP) and another specific for I-Ak plus influenza virus have been demonstrated to cross-react with DBA/2 cells. Genetic and serological analyses have shown that each clone recognizes its respective priming antigen in association with self-major histocompatibility complex (MHC) determinants and each recognizes DBA/2 minor H antigens in association with allo I-Ad MHC antigens. Further analysis of these clones suggests (a) that the allo I-Ad MHC epitopes recognized by these clones are not shared with self-I-A epitopes, (b) that the virus or BP antigens do not cross-react with DBA/2 minor H antigens, (c) that these clones recognize different determinants on the DBA/2 minor H antigens, and (d) that there is a requirement for a specific association between the different MHC antigens and the non-MHC antigens to stimulate these clones. This specific associative recognition argues strongly for the "altered self" hypothesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|