Phosphate-32 colloid radiosynovectomy in hemophilia: outcome of 125 procedures
Autor: | James V. Luck, Herrick J. Siegel, Cristobal Quinones, M. E. Siegel |
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Rok vydání: | 2001 |
Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Synovectomy Hemophilia A Phosphates Synovitis Chromium Compounds Arthropathy Hemarthrosis medicine Coagulopathy Humans Orthopedics and Sports Medicine Colloids Range of Motion Articular Child business.industry General Medicine Middle Aged medicine.disease Surgery Treatment Outcome Effusion Child Preschool Ambulatory Chronic Disease Quality of Life Female business Complication |
Zdroj: | Clinical orthopaedics and related research. (392) |
ISSN: | 0009-921X |
Popis: | Radiosynovectomy offers a potentially effective, minimally invasive option for patients with chronic hemarthrosis and synovitis. The long-term outcome of patients with hemophilia who were treated with phosphate-32 chromic phosphate radiosynovectomy was evaluated. One hundred twenty-five procedures in 81 patients were done. Two- to 10-year followup by age and joint included joint bleeding and quality-of-life assessment. In addition, a relative cost comparison, scintigraphic imaging, and evaluation of biodistribution of the radionuclide were done. Of 125 procedures, 54% resulted in complete cessation of bleeding into the treated joint after the procedure, and 73% of patients reported improved mobility of the treated joint. Of patients 18 years old and younger, 79% had a greater than 75% reduction in bleeding incidence, and of patients older than 40 years, only 56% had a similar reduction. Seventy-nine percent of patients surveyed had a significant improvement in quality of life attributable to the treated joint. No evidence of significant leakage was observed. Billing records analysis indicated that radiosynovectomy costs less than 5% of surgical synovectomy. Phosphate-32 chromic phosphate radiosynovectomy is a clinically useful, safe, and cost-effective outpatient procedure in the treatment of patients with chronic hemarthrosis and synovitis. |
Databáze: | OpenAIRE |
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