Templated Oligosaccharide Synthesis: The Linker Effect on the Stereoselectivity of Glycosylation
| Autor: | Xiao G. Jia, Alexei V. Demchenko, Papapida Pornsuriyasak, Sophon Kaeothip |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Bisphenol A Glycosylation 010405 organic chemistry Organic Chemistry Oligosaccharides Stereoisomerism 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Article 0104 chemical sciences chemistry.chemical_compound chemistry Intramolecular force Carbohydrate Conformation Stereoselectivity Trisaccharide Physical and Theoretical Chemistry Oligosaccharide synthesis Linker |
| Popis: | A new method for intramolecular oligosaccharide synthesis that is conceptually related to the general molecular clamp approach is introduced. Exceptional α-selectivity has been achieved in a majority of applications. Unlike other related concepts, this approach is based on the bisphenol A template, which allows one to connect multiple building blocks to perform templated oligosaccharide synthesis with complete stereoselectivity. This principle was demonstrated by the synthesis of an α,α-linked trisaccharide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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