Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice
| Autor: | Jin-Joo Hue, Sang-Hwa Lee, Jae-Hwang Jeong, Ki Nam Lee, Seong-woon Jeong, Young Ho Lee, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
obesity PPAR-γ medicine.medical_specialty Time Factors Linoleic acid Conjugated linoleic acid Mice Obese Blood lipids conjugated linoleic acid C57BL/6J ob/ob mouse Diglycerides Eating Mice chemistry.chemical_compound Blood serum Internal medicine medicine Animals Linoleic Acids Conjugated Globules of fat Diglyceride integumentary system General Veterinary Triglyceride Cholesterol Body Weight food and beverages Lipids Mice Inbred C57BL PPAR gamma Disease Models Animal Endocrinology Adipose Tissue Gene Expression Regulation Liver chemistry Original Article diglyceride lipids (amino acids peptides and proteins) Anti-Obesity Agents Blood Chemical Analysis |
| Zdroj: | Journal of Veterinary Science |
| ISSN: | 1229-845X |
| DOI: | 10.4142/jvs.2009.10.3.189 |
| Popis: | This study was to investigate the anti-obesity effects of diglyceride (DG)-conjugated linoleic acid (CLA) containing 22% CLA as fatty acids in C57BL/6J ob/ob male mice. There were four experimental groups including vehicle control, DG, CLA, and DG-CLA. The test solutions of 750 mg/kg dose were orally administered to the mice everyday for 5 weeks. CLA treatments significantly decreased mean body weight in the obese mice throughout the experimental period compared to the control (p < 0.01). All test solutions significantly decreased the levels of triglyceride, glucose and free fatty acids in the serum compared with control (p < 0.05). The levels of total cholesterol were also significantly reduced in DG and DG-CLA groups compared with the control group (p < 0.05). CLA significantly decreased weights of renal and epididymal fats compared with the control (p < 0.05). DG and DG-CLA also significantly decreased the epididymal fat weights compared with the control (p < 0.05). A remarkable decrease in the number of lipid droplets and fat globules was observed in the livers of mice treated with DG, CLA, and DG-CLA compared to control. Treatments of DG and CLA actually increased the expression of peroxisome proliferator-activated receptor gamma. These results suggest that DG-CLA containing 22% CLA have a respectable anti-obesity effect by controlling serum lipids and fat metabolism. |
| Databáze: | OpenAIRE |
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