Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine
| Autor: | Norton W. Milgram, Shikha Snigdha, Christina de Rivera, Carl W. Cotman |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Aging Longitudinal study Memory Long-Term Antioxidant medicine.medical_treatment Coenzymes Physiology Biology Antioxidants Developmental psychology law.invention 03 medical and health sciences chemistry.chemical_compound Cognition Dogs 0302 clinical medicine Randomized controlled trial law medicine Animals Cognitive decline Acetylcarnitine Thioctic Acid General Neuroscience Disease Models Animal Lipoic acid 030104 developmental biology chemistry Dietary Supplements Animal Nutritional Physiological Phenomena Female Neurology (clinical) Geriatrics and Gerontology Cognition Disorders 030217 neurology & neurosurgery Developmental Biology medicine.drug |
| Zdroj: | Neurobiology of Aging. 37:171-178 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2015.09.015 |
| Popis: | A growing body of research has focused on modifiable risk factors for prevention and attenuation of cognitive decline in aging. This has led to an unprecedented interest in the relationship between diet and cognitive function. Several preclinical and epidemiologic studies suggest that dietary intervention can be used to improve cognitive function but randomized controlled trials are increasingly failing to replicate these findings. Here, we use a canine model of aging to evaluate the effects of specific components of diet supplementation which contain both antioxidants and a combination of mitochondrial cofactors (lipoic acid [LA] and acetyl-l-carnitine) on a battery of cognitive functions. Our data suggest that supplementation with mitochondrial cofactors, but not LA or antioxidant alone, selectively improve long-term recall in aged canines. Furthermore, we found evidence that LA alone could have cognitive impairing effects. These results contrast to those of a previous longitudinal study in aged canine. Our data demonstrate that one reason for this difference may be the nutritional status of animals at baseline for the 2 studies. Overall, this study suggests that social, cognitive, and physical activity together with optimal dietary intake (rather than diet alone) promotes successful brain aging. |
| Databáze: | OpenAIRE |
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