Prenatal Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Children’s Intelligence at 5 Years of Age in a Prospective Cohort Study in Poland
| Autor: | Maria Butscher, Zhigang Li, Susan Edwards, David Camann, Wieslaw Jedrychowski, Agnieszka Kiełtyka, Elzbieta Flak, Shuang Wang, Virginia Rauh, Elzbieta Mroz, Frederica P. Perera |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male prenatal Adolescent Health Toxicology and Mutagenesis air pollution Intelligence 010501 environmental sciences 01 natural sciences in utero environmental 03 medical and health sciences Young Adult 0302 clinical medicine Air pollutants Pregnancy Environmental health 11. Sustainability medicine Raven Humans 030212 general & internal medicine Prospective Studies Young adult Polycyclic Aromatic Hydrocarbons Prospective cohort study Prenatal exposure development 0105 earth and related environmental sciences child Air Pollutants business.industry Research Public Health Environmental and Occupational Health medicine.disease El Niño Child Preschool Prenatal Exposure Delayed Effects Children's Health Polycyclic Hydrocarbons Female Poland business Cohort study ETS |
| Zdroj: | Environmental Health Perspectives |
| ISSN: | 1552-9924 0091-6765 |
| Popis: | Background In this prospective cohort study of Caucasian mothers and children in Krakow, Poland, we evaluated the role of prenatal exposure to urban air pollutants in the pathogenesis of neurobehavioral disorders. Objectives The objective of this study was to investigate the relationship between prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child intelligence at 5 years of age, controlling for potential confounders suspected to play a role in neurodevelopment. Methods A cohort of pregnant, healthy, nonsmoking women was enrolled in Krakow, Poland, between 2001 and 2006. During pregnancy, participants were invited to complete a questionnaire and undergo 48-hr personal air monitoring to estimate their babies’ exposure, and to provide a blood sample and/or a cord blood sample at the time of delivery. Two hundred fourteen children were followed through 5 years of age, when their nonverbal reasoning ability was assessed using the Raven Coloured Progressive Matrices (RCPM). Results We found that higher (above the median of 17.96 ng/m3) prenatal exposure to airborne PAHs (range, 1.8–272.2 ng/m3) was associated with decreased RCPM scores at 5 years of age, after adjusting for potential confounding variables (n = 214). Further adjusting for maternal intelligence, lead, or dietary PAHs did not alter this association. The reduction in RCPM score associated with high airborne PAH exposure corresponded to an estimated average decrease of 3.8 IQ points. Conclusions These results suggest that prenatal exposure to airborne PAHs adversely affects children’s cognitive development by 5 years of age, with potential implications for school performance. They are consistent with a recent finding in a parallel cohort in New York City. |
| Databáze: | OpenAIRE |
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