Impact of physical exercise on alterations in the skeletal muscle in patients with chronic heart failure
| Autor: | Doring C, Schuler G, Adams |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Proteasome Endopeptidase Complex
medicine.medical_specialty Apoptosis Inflammation Strain (injury) Physical exercise Exercise intolerance Oxidative Phosphorylation Physical Conditioning Animal Internal medicine medicine Animals Humans Insulin-Like Growth Factor I Exercise physiology Muscle Skeletal Heart Failure Ubiquitin business.industry Skeletal muscle Cardiorespiratory fitness medicine.disease Mitochondria Oxidative Stress medicine.anatomical_structure Heart failure Chronic Disease Cardiology Cytokines medicine.symptom business |
| Zdroj: | Frontiers in Bioscience. 13:302 |
| ISSN: | 1093-4715 1093-9946 |
| DOI: | 10.2741/2680 |
| Popis: | Chronic heart failure (CHF) is a condition characterized by exercise intolerance. The level of activity tolerated by an individual cannot be predicted by classical parameters of left ventricular performance. Therefore, considerable attention has been focused on the role of peripheral factors such as skeletal muscle, which are determinants of work capacity. In recent years, many alterations in the skeletal muscle have been described in patients with chronic heart failure. This knowledge has dramatically changed the treatment of patients with CHF. Previously, patients were asked to avoid excessive strain and physical exercise. Recently, however, patients are asked to participate in a supervised physical training program to increase their exercise capacity and to counteract the molecular changes occurring in the skeletal muscle. This review will focus on molecular and biochemical alterations especially in the skeletal muscle and how these alterations are influenced by exercise training finally contributing to better skeletal muscle performance. |
| Databáze: | OpenAIRE |
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