Midazolam versus diazepam for combined esophogastroduodenoscopy and colonoscopy

Autor: D. E. Brouillette, Young-Kul Yoo, Shashi Kumar, David M. Berman, Ralph E. Tarter, Joseph Carra, Mirza Kajani, Robert Leventhal, D. H. Van Thiel
Rok vydání: 1989
Předmět:
Zdroj: Digestive Diseases and Sciences. 34:1265-1271
ISSN: 1573-2568
0163-2116
DOI: 10.1007/bf01537276
Popis: This study compares the effects of two different benzodiazepines used for conscious sedation during combined upper gastrointestinal endoscopy (EGD) and colonoscopy. Subjects were assessed for their degree of analgesia and amnesia for the procedure, prior experience with endoscopy, and willingness to undergo another similar procedure should such be necessary. The patients were randomized single blind to receive either midazolam or diazepam for their preprocedure sedation. The amount of preprocedure sedation utilized was determined by titration of the dose to achieve slurring of speech. Prior to receiving either agent, the subjects were shown a standard card containing pictures of 10 common objects, were asked to name and remember them, and were told they would be “quizzed” (at 30 min and 24 hr) after being sedated for their recollection as to the objects pictured on the card. Each subject filled out a questionnaire addressing their perceived discomfort during the endoscopic procedure and their memory of the procedure 24 hr after the procedure. Sixty-three percent of the midazolam-sedated subjects reported total amnesia for their colonoscopy vs 20% of diazepam-sedated patients (P
Databáze: OpenAIRE
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