Biochemical markers of contamination in fish toxicity tests
| Autor: | Marcela Havelkova, Helena Modra, Zdeňka Svobodová, Jana Blahova, Zuzana Siroka, Ivana Haluzova |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Health Toxicology and Mutagenesis Toxicology Cyprinus chemistry.chemical_compound Common carp Metribuzin Internal medicine CYP medicine GSH GST Pharmacology fish biology Cytochrome P450 Glutathione Pesticide biology.organism_classification Endocrinology chemistry Toxicity biology.protein Original Article EROD Xenobiotic |
| Zdroj: | Interdisciplinary Toxicology |
| ISSN: | 1337-9569 |
| Popis: | Markers of xenobiotic metabolization (cytochrome P450, ethoxyresorufin-O-deethylase, glutathione and glutathione-S-transferase) were investigated in the liver of the common carp Cyprinus carpio after 28-day exposure to different pesticide formulations. The fish exposed to herbicide Sencor 70 WG (metribuzin 700 g/kg) of 0.25 and 2.5 mg/l showed no change in cytochrome P450 and activity of ethoxyresorufin-O-deethylase when compared to control. Successor 600 (pethoxamid 600 g/l) of 0.06; 0.22 and 0.60 mg/l did not affect either cytochrome P450 or the activity of ethoxyresorufin-O-deethylase. However, in fish exposed to Successor 600 of 0.22 and 0.60 mg/l, there was a rise in glutathione and in the activity of glutathione-S-transferase (p |
| Databáze: | OpenAIRE |
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