Therapeutic effects of various renin angiotensin modulators on hyperglycemia-induced cataract formation in Sprague Dawley rats
| Autor: | Rajesh Choudhary, Jaya Shree, Surendra H. Bodakhe |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Angiotensins
Angiotensin-Converting Enzyme Inhibitors Pharmacology 030226 pharmacology & pharmacy Cataract Diabetes Mellitus Experimental Rats Sprague-Dawley Angiotensin Receptor Antagonists 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Diabetes mellitus Renin Renin–angiotensin system Sprague dawley rats Animals Humans Medicine Enalapril business.industry Therapeutic effect General Medicine Aliskiren medicine.disease Streptozotocin Rats Ophthalmology chemistry Hyperglycemia 030221 ophthalmology & optometry business Olmesartan medicine.drug |
| Zdroj: | European Journal of Ophthalmology. 31:2360-2369 |
| ISSN: | 1724-6016 1120-6721 |
| Popis: | Objects: Our previous research work reported the beneficial effects of angiotensin receptor blockers (ARBs) for the treatment of diabetes associated cataract which was induced by streptozotocin (STZ). The current study, evaluated the effects of topical administration of various renin angiotensin modulators on STZ-induced cataracts in rats. Methods: Single dose of STZ (60 mg/kg, i.p.) was administered in the rats to induce diabetes. Animals were divided into normal and diabetic rats. Normal rats were administered with single dose of sodium citrate buffer (0.1 M, 10ml/kg, i.p.). Diabetic animals were divided into various treatment groups, each group contains six animals and received aliskiren, olmesartan, enalapril, and angiotensin 1–7 at a dose of 0.5% w/v topically on the cornea of the eye for a period of 8 weeks. During experimental protocol morphology of the eyes and lenticular opacity were monitored. Animals were sacrificed after 8 weeks of drug treatment, and various cataractogenic biochemical parameters were assessed. Results: Topical administrations with aliskiren, enalapril, olmesartan, and angiotensin 1–7 showed non-significant alterations in the blood glucose level, but significantly decreased lenticular opacity, restored antioxidant level, restored MDA level and Nitrite content, and decreased the onset of cataract formation. Conclusion: Overall, our findings suggest that topical treatment with renin angiotensin modulators delayed the onset of diabetes-induced cataract formation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|