An international multicenter comparison of time-SLIP unenhanced MR angiography and contrast-enhanced CT angiography for assessing renal artery stenosis: the renal artery contrast-free trial
| Autor: | Zhengyu Jin, Violeta Catalá, Venkata S. Katabathina, Timothy S. E. Albert, Antoine Prot, Nobuo Tomizawa, Masaaki Akahane, Isabelle Parienty, Huadan Xue, Jorge E. Lopera, Xavier Alomar, Nancy Yellin |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Internationality Enhanced ct Contrast Media Renal artery stenosis Renal Artery Obstruction Sensitivity and Specificity Young Adult Multicenter trial medicine.artery medicine Humans Radiology Nuclear Medicine and imaging Single-Blind Method Renal artery Aged Aged 80 and over Observer Variation medicine.diagnostic_test business.industry Mr angiography Reproducibility of Results General Medicine Free trial Middle Aged medicine.disease Image Enhancement Stenosis Angiography Radiology business Tomography X-Ray Computed Magnetic Resonance Angiography |
| Zdroj: | AJR. American journal of roentgenology. 204(1) |
| ISSN: | 1546-3141 |
| Popis: | The unenhanced MR angiography (MRA) technique time-spatial labeling inversion pulse (time-SLIP) may provide a safe alternative for evaluating the renal arteries for stenosis. This international multicenter trial tested the hypothesis that time-SLIP unenhanced MRA is accurate and robust for assessing the renal arteries for stenosis in comparison with contrast-enhanced CT angiography (CTA).Four centers (United States, Europe, Asia) enrolled 75 patients (average age ± SD, 58 ± 13 years; 41 [55%] men and 34 [45%] women). Each patient underwent abdominal contrast-enhanced CTA and abdominal unenhanced MRA using time-SLIP with balanced steady-state free precession. All images were visually assessed for quality (arterial signal intensity) and for the absence or presence of renal artery stenosis (≤ 50% or50% stenosis, respectively). In addition, for arteries with any visible disease, the severity of the stenosis was quantified. Two blinded readers evaluated each study. No arteries were excluded from analysis.Unenhanced MRA image quality was excellent for 56 of 75 patients (75%) and good for 16 of 75 patients (21%). CTA was used as the reference standard and showed that 23 of 161 renal arteries (14.3%) had stenosis50%. Unenhanced MRA correctly classified 17 of the 23 renal arteries with50% stenosis and correctly classified 128 of the 138 renal arteries as not having disease (≤ 50% stenosis) to yield a sensitivity of 74%, specificity of 93%, and accuracy of 90% (χ(2) = 0.56; p = 0.45, no statistically significant difference). Of the 16 misclassified arteries, only three had a clinically relevant misclassification (CTA ≥ 70% stenosis and unenhanced MRA ≤ 50% stenosis or unenhanced MRA ≥ 70% stenosis and CTA ≤ 50% stenosis). On average, measured stenotic severity (n = 28 arteries) was similar for unenhanced MRA (64% ± 17%) and CTA (62% ± 16%) (p = 0.51).Compared with contrast-enhanced CTA, the unenhanced MRA technique time-SLIP shows promise for assessing the renal arteries for stenosis. The unenhanced MRA technique time-SLIP may provide a safe alternative for evaluating the renal arteries for stenosis. |
| Databáze: | OpenAIRE |
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