Total retinal thickness: a neglected factor in the evaluation of inner retinal thickness

Autor: Mark Banghart, Kyungmoo Lee, Mozhdeh Bahrainian, Kristen Staggers, Christopher Amos, Yao Liu, Amitha Domalpally, Benjamin J Frankfort, Elliott H Sohn, Michael Abramoff, Roomasa Channa
Rok vydání: 2022
Předmět:
Zdroj: BMJ Open Ophthalmology. 7:e001061
ISSN: 2397-3269
Popis: AimTo determine whether macular retinal nerve fibre layer (mRNFL) and ganglion cell-inner plexiform layer (GC-IPL) thicknesses vary by ethnicity after accounting for total retinal thickness.MethodsWe included healthy participants from the UK Biobank cohort who underwent macula-centred spectral domain-optical coherence tomography scans. mRNFL and GC-IPL thicknesses were determined for groups from different self-reported ethnic backgrounds. Multivariable regression models adjusting for covariables including age, gender, ethnicity and refractive error were built, with and without adjusting for total retinal thickness.Results20237 participants were analysed. Prior to accounting for total retinal thickness, mRNFL thickness was on average 0.9 μm (−1.2, –0.6; pConclusionsThe previously reported ethnic differences in layer thickness among groups are likely driven by differences in total retinal thickness. Our results suggest using layer thickness ratio (retinal layer thicknesses/total retinal thickness) rather than absolute thickness values when comparing retinal layer thicknesses across groups.
Databáze: OpenAIRE