Effects of a novel anti-inflammatory retinoid-like 2,4,6,8-nonatetraenoic acid on the immunological changes associated with adjuvant-induced arthritis
| Autor: | John W. Coffey, A. C. Hanglow, Michael Rosenberger, H. Bachmann |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Interleukin 2 medicine.medical_specialty Immunology Arthritis Tretinoin Spleen Stimulation In Vitro Techniques Lymphocyte Activation Immune system Internal medicine medicine Splenocyte Animals Pharmacology business.industry Anti-Inflammatory Agents Non-Steroidal Interleukin medicine.disease Arthritis Experimental Rats medicine.anatomical_structure Endocrinology Rats Inbred Lew Cell culture Interleukin-2 business Immunosuppressive Agents Interleukin-1 medicine.drug |
| Zdroj: | International Journal of Immunopharmacology. 12:703-712 |
| ISSN: | 0192-0561 |
| DOI: | 10.1016/0192-0561(90)90032-i |
| Popis: | Proliferative responses to the T-cell mitogen, Con A, were markedly suppressed in spleen cells isolated from rats 12-16 days following induction of adjuvant-induced arthritis (AA). These responses were only partially restored following removal of plastic-adherent cells (AC-depleted). Prophylactic treatment of AA rats with a novel anti-inflammatory retinoid-like 2,4,6,8-nonatetraenoic acid, Ro 23-6457, increased mitogen-induced proliferative responses in spleen cells, particularly in AC-depleted cultures. Treatment of AA rats with Ro 23-6457 significantly increased Con A-induced IL-2 production by both unseparated and AC-depleted spleen cells. Although exogenous IL-2 did not restore proliferative responses to Con A-stimulated spleen cells from vehicle-treated AA rats, responses in AC-depleted cells from Ro 23-6457-treated AA rats were further enhanced by the addition of IL-2. Following stimulation with LPS, supernatants from cultures of adherent spleen cells isolated from AA rats contained more IL-1 (expressed as units/ml) than cultures from normal rats. Treatment of AA rats with a high dose of Ro 23-6457 normalised IL-1 levels in these cultures. Treatment of normal rats with Ro 23-6457 had no significant effects on any parameter tested. These data suggest that Ro 23-6457's modulation of certain disease-associated alterations in immune function in AA rats may contribute to its anti-inflammatory activity. |
| Databáze: | OpenAIRE |
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