Hyperthermia in Humans Enhances Interferon-γ Synthesis and Alters the Peripheral Lymphocyte Population
| Autor: | R.S. Elizondo, E.B. Walker, H. Martinez-Valdez, James F. Downing, Milton W. Taylor |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Hyperthermia Lymphocyte Immunology Cell Population Biology Body Temperature Interferon-gamma Leukocyte Count Virology medicine Humans Interferon gamma Lymphocytes education education.field_of_study Macrophages Granulocytosis Hyperthermia Induced T lymphocyte medicine.disease In vitro medicine.anatomical_structure Interleukin-2 medicine.drug |
| Zdroj: | Journal of Interferon Research. 8:143-150 |
| ISSN: | 0197-8357 |
| DOI: | 10.1089/jir.1988.8.143 |
| Popis: | Induction of hyperthermia (39 degrees C) in human volunteers by immersion in warm water (41-45 degrees C) rapidly alters the cell populations in the peripheral blood. In addition to granulocytosis, there is an alteration of the normal ratios among T-lymphocyte subsets. Following in vitro mitogen stimulation, lymphocytes from hyperthermic individuals produce as much as 10-fold more interferon-gamma (IFN-gamma) than cells withdrawn at basal core temperatures from the same individuals. A temperature threshold of 39 degrees C for this response suggests potential relevance to fever. No change was noted in the activity of the macrophage population. The possible involvement of interleukin-2 (IL-2) in this enhanced production is discussed. No changes were noted in the circulating levels of IFN-gamma. |
| Databáze: | OpenAIRE |
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