Surface modification of doxorubicin-loaded nanoparticles based on polydopamine with pH-sensitive property for tumor targeting therapy

Autor: Meihua Han, Lei Zhao, Dongdong Bi, Haowen Li, Xiangtao Wang, Runqi Yu, Yifei Guo
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Indoles
Polymers
arginine-glycine-aspartate
Pharmaceutical Science
Nanoparticle
02 engineering and technology
01 natural sciences
chemistry.chemical_compound
Mice
Drug Delivery Systems
Polylactic Acid-Polyglycolic Acid Copolymer
Zeta potential
Drug Carriers
Mice
Inbred BALB C
General Medicine
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
PLGA
Female
0210 nano-technology
Oligopeptides
medicine.drug
Research Article
education
Mice
Nude
Conjugated system
010402 general chemistry
folate
doxorubicin
Folic Acid
ph-sensitive
In vivo
Cell Line
Tumor
medicine
Animals
Humans
Doxorubicin
Lactic Acid
Particle Size
polydopamine
tumor targeting
lcsh:RM1-950
technology
industry
and agriculture
0104 chemical sciences
Drug Liberation
lcsh:Therapeutics. Pharmacology
chemistry
Biophysics
Surface modification
Nanoparticles
Nanocarriers
Polyglycolic Acid
HeLa Cells
Zdroj: Drug Delivery, Vol 25, Iss 1, Pp 564-575 (2018)
Drug Delivery
ISSN: 1521-0464
1071-7544
Popis: One major challenge of current surface modification of nanoparticles is the demand for chemical reactive polymeric layers, such modification is always complicated, inefficient, and may lead the polymer lose the ability to encapsulate drug. To overcome this limitation, we adopted a pH-sensitive platform using polydopamine (PDA) as a way of functionalizing nanoparticles (NPs) surfaces. All this method needed to be just a brief incubation in weak alkaline solution of dopamine, which was simple and applicable to a variety of polymer carriers regardless of their chemical reactivity. We successfully conjugated the doxorubicin (DOX)-PDA-poly (lactic-co-glycolic acid) (PLGA) NPs with two typical surface modifiers: folate (FA) and a peptide (Arg-Gly-Asp, RGD). The DOX-PDA-FA-NPs and DOX-PDA-RGD-NPs (targeting nanoparticles) were characterized by particle size, zeta potential, and surface morphology. They were quite stable in various physiological solutions and exhibited pH-sensitive property in drug release. Compared to DOX-NPs, the targeting nanoparticles possessed an excellent targeting ability against HeLa cells. In addition, the in vivo study demonstrated that targeting nanoparticles achieved a tumor inhibition rate over 70%, meanwhile prominently decreased the side effects of DOX and improve drug distribution in tumors. Our studies indicated that the DOX-PLGA-NPs modified with PDA and various functional ligands are promising nanocarriers for targeting tumor therapy.
Databáze: OpenAIRE
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