Cumulative influence of parity-related genomic changes in multiple sclerosis
| Autor: | Divya Mehta, Anjali K. Henders, Shivangi Wani, Naomi R. Wray, Pamela A. McCombe, Leanne Wallace |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
0301 basic medicine Multiple Sclerosis Immunology Biology Bioinformatics 03 medical and health sciences 0302 clinical medicine Pregnancy Gene expression medicine Animals Humans Immunology and Allergy Gene Regulation of gene expression Multiple sclerosis DNA Methylation medicine.disease Rats Pregnancy Complications Parity 030104 developmental biology Neurology DNA methylation Female Axon guidance Neurology (clinical) Parity (mathematics) 030217 neurology & neurosurgery Genome-Wide Association Study |
| Zdroj: | Journal of Neuroimmunology. 328:38-49 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2018.12.004 |
| Popis: | Pregnancy reduces the frequency of relapses in Multiple Sclerosis (MS) and parity also has a beneficial long term effect on disease outcome. We aimed to uncover the biological mechanisms underlying the beneficial long-term effects of parity in MS. Genome-wide gene expression revealed 574 genes associated with parity; 38.3% showed significant DNA methylation changes (enrichment p = 0.029). These genes overlapped with previous MS genes in humans and a rat MS model and were overrepresented within axon guidance (P = 1.6e-05), developmental biology (P = 0.0094) and cell-cell communication (P = 0.019) pathways. This gene regulation could provide a basis for a protective effect of parity on the long-term outcome of MS. |
| Databáze: | OpenAIRE |
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