Pulmonary pericytes regulate lung morphogenesis
| Autor: | Jeffrey L. Wrana, Rodrigo Diéguez-Hurtado, Ralf H. Adams, Britta Trappmann, Susanne Adams, Sakiko Kato-Azuma, Do Young Park, Katsuhiro Kato, Gou Young Koh, Martin Stehling, Seon Pyo Hong |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Cell signaling Science Primary Cell Culture Morphogenesis General Physics and Astronomy Neovascularization Physiologic Cell Cycle Proteins Mice Transgenic Biology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Mice medicine Angiopoietin-1 Animals lcsh:Science Autocrine signalling Cells Cultured Adaptor Proteins Signal Transducing Hippo signaling pathway Multidisciplinary Regeneration (biology) Endothelial Cells YAP-Signaling Proteins General Chemistry Phosphoproteins Cell biology Mice Inbred C57BL Pulmonary Alveoli 030104 developmental biology lcsh:Q Hepatocyte growth factor Female Lung morphogenesis Signal transduction Pericytes Acyltransferases medicine.drug Signal Transduction Transcription Factors |
| Zdroj: | Nature Communications Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
| ISSN: | 2041-1723 |
| Popis: | Blood vessels are essential for blood circulation but also control organ growth, homeostasis, and regeneration, which has been attributed to the release of paracrine signals by endothelial cells. Endothelial tubules are associated with specialised mesenchymal cells, termed pericytes, which help to maintain vessel wall integrity. Here we identify pericytes as regulators of epithelial and endothelial morphogenesis in postnatal lung. Mice lacking expression of the Hippo pathway components YAP and TAZ in pericytes show defective alveologenesis. Mutant pericytes are present in normal numbers but display strongly reduced expression of hepatocyte growth factor leading to impaired activation of the c-Met receptor, which is expressed by alveolar epithelial cells. YAP and TAZ are also required for expression of angiopoietin-1 by pulmonary pericytes, which also controls hepatocyte growth factor expression and thereby alveologenesis in an autocrine fashion. These findings establish that pericytes have important, organ-specific signalling properties and coordinate the behavior of epithelial and vascular cells during lung morphogenesis. Pericytes surround endothelial tubules and help maintain the integrity of blood vessels. Here the authors show that pericytes regulate lung morphogenesis via paracrine signalling controlled by components of the Hippo pathway. |
| Databáze: | OpenAIRE |
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