Clinical Outcome of Surgically Treated Leiomyosarcoma of the Extremities: A Retrospective Overview
| Autor: | Michiel A. J. van de Sande, Jozef Michielsen, Sander Dijkstra, Veroniek M. van Praag, Thomas Schubert, Felix Shumelinsky, Annelies Van Beeck, Bilal Kapanci, Johan Somville, Dietmar Dammerer |
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| Přispěvatelé: | UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Leiomyosarcoma Cancer Research medicine.medical_specialty sarcoma Biopsy medicine.medical_treatment clinical outcome extremity surgical Adjuvant therapy Overall survival Humans Medicine Aged Neoplasm Staging Retrospective Studies Aged 80 and over Adjuvant radiotherapy business.industry Soft tissue sarcoma Extremities General Medicine Middle Aged soft-tissue sarcoma Prognosis medicine.disease Combined Modality Therapy Immunohistochemistry Magnetic Resonance Imaging Tumor Burden Surgery body regions Radiation therapy Treatment Outcome oncologic Oncology Female Human medicine Sarcoma business Follow-Up Studies |
| Zdroj: | Anticancer research, Vol. 40, no. 9, p. 5319-5325 (2020) Anticancer research Anticancer Research, 40(9), 5319-5325. INT INST ANTICANCER RESEARCH |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.14539 |
| Popis: | Aim: This study was interested in extremity leiomyosarcoma with focus on clinical outcome after surgery with or without adjuvant therapy. Patients and Methods: A retrospective case series of all patients with leiomyosarcoma, surgically treated between 2000 and 2015 and a minimum follow-up of 2 years, was drawn from institutional databases in Belgium and the Netherlands. Postoperative complications were reported with the Radiation Therapy Oncology Group (RTOG) and the Henderson classification. Results: Seventy-five patients were operated on, of whom 47 underwent (neo)adjuvant therapy. Infection was observed in 11 patients, seven associated with (neo)adjuvant radiotherapy. Dermatological complaints vvere observed in 26 patients, 10 associated with (neo)adjuvant radiotherapy. Overall survival was 60%. Local recurrence occurred in 11 (15%) patients. Conclusion: This study describes favourable clinical outcome following (neo)adjuvant radiotherapy. In the future, larger databases on leiomyosarcoma should enhance the power of these findings and define the benefits of adjuvant therapy in leiomyosarcoma. |
| Databáze: | OpenAIRE |
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