Selenium Concentrations and Mortality Among Community-Dwelling Older Adults: Results from ilSIRENTE Study
| Autor: | Silvia Bustacchini, Fabrizia Lattanzio, Andrea Russo, Silvia Giovannini, Graziano Onder, G. Di Stefano, Roberto Bernabei, Raffaella Moresi, Francesco Landi |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Frail Elderly Longevity Medicine (miscellaneous) Physiology chemistry.chemical_element 030204 cardiovascular system & hematology medicine.disease_cause Serum selenium Older population 03 medical and health sciences Selenium 0302 clinical medicine medicine 80 and over Humans 030212 general & internal medicine Prospective Studies Prospective cohort study Aged Aged 80 and over Inflammation Nutrition and Dietetics Redox homeostasis business.industry Confounding Settore MED/09 - MEDICINA INTERNA mortality chemistry Italy Female Risk of death Independent Living Geriatrics and Gerontology business Oxidative stress Settore MED/34 - MEDICINA FISICA E RIABILITATIVA |
| Popis: | Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population. to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults. Data are from the ‘Invecchiamento e Longevita nel Sirente’ (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up. Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium. A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92). Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables. |
| Databáze: | OpenAIRE |
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