A Quantitative Proteomics Approach to Clinical Research with Non-Traditional Samples
| Autor: | Eric Miranda, Horacio Serrano, Rígel Licier |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
quantitative proteomics Pathology medicine.medical_specialty precision medicine Clinical Biochemistry Quantitative proteomics MS/MS clinical samples screening lcsh:QR1-502 Aqueous humor Computational biology Biochemistry lcsh:Microbiology Article 03 medical and health sciences Nipple Aspirate Fluid Structural Biology medicine Lavage fluid Molecular Biology business.industry Precision medicine 030104 developmental biology Clinical research Proteome business |
| Zdroj: | Proteomes; Volume 4; Issue 4; Pages: 31 Proteomes Proteomes, Vol 4, Iss 4, p 31 (2016) |
| ISSN: | 2227-7382 |
| DOI: | 10.3390/proteomes4040031 |
| Popis: | The proper handling of samples to be analyzed by mass spectrometry (MS) can guarantee excellent results and a greater depth of analysis when working in quantitative proteomics. This is critical when trying to assess non-traditional sources such as ear wax, saliva, vitreous humor, aqueous humor, tears, nipple aspirate fluid, breast milk/colostrum, cervical-vaginal fluid, nasal secretions, bronco-alveolar lavage fluid, and stools. We intend to provide the investigator with relevant aspects of quantitative proteomics and to recognize the most recent clinical research work conducted with atypical samples and analyzed by quantitative proteomics. Having as reference the most recent and different approaches used with non-traditional sources allows us to compare new strategies in the development of novel experimental models. On the other hand, these references help us to contribute significantly to the understanding of the proportions of proteins in different proteomes of clinical interest and may lead to potential advances in the emerging field of precision medicine. |
| Databáze: | OpenAIRE |
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