Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3

Autor:	Angela Smallwood, Jodi K. Muckelbauer, Sarah Cox, C. Anne Higley, Steven P. Seitz, Eddy W. Yue, George L. Trainor, Dimeo Susan, Haiying Chen, Robert H. Grafstrom, Pamela A. Benfield, Jay A. Markwalder, Catherine R. Burton, Chong Hwan Chang
Rok vydání:	2004
Předmět:	Clinical Biochemistry Drug Evaluation Preclinical Pharmaceutical Science Biochemistry Heterocyclic Compounds Cyclin-dependent kinase Cell Line Tumor Drug Discovery medicine Humans Enzyme Inhibitors Protein kinase A Fibroblast Molecular Biology chemistry.chemical_classification biology Chemistry Organic Chemistry Fibroblasts Blood proteins Cyclin-Dependent Kinases In vitro medicine.anatomical_structure Enzyme Enzyme inhibitor Cell culture biology.protein Pyrazoles Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 14:343-346
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2003.11.008
Popis:	New indeno[1,2-c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with excellent activity against tumor cells. The most advanced compound retains cell culture activity even in the presence of human serum proteins. The most advanced compound did not kill the normal fibroblast line AG1523.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eca9874d090f1248663ed651625ea7e https://doi.org/10.1016/j.bmcl.2003.11.008 Zobrazit plný text záznamu Full Text from ScienceDirect