Intron Retained, Transcript Detained: Intron Retention as a Hallmark of the Quiescent Satellite Cell State
| Autor: | F. Jeffrey Dilworth, Radmila Kovac, Matthew Man-Kin Wong, Kiran Nakka |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Satellite Cells Skeletal Muscle Muscles Mesenchymal stem cell Developmental cell Intron Cell Differentiation Cell state Cell Biology Biology Introns General Biochemistry Genetics and Molecular Biology Cell biology Transcriptome 03 medical and health sciences 0302 clinical medicine book.journal Molecular Biology book Cell Division 030217 neurology & neurosurgery 030304 developmental biology Developmental Biology Fixation (histology) |
| Zdroj: | Developmental Cell. 53:623-625 |
| ISSN: | 1534-5807 |
| DOI: | 10.1016/j.devcel.2020.05.028 |
| Popis: | Molecular signatures defining quiescence in muscle satellite cells (mSCs) remain enigmatic. In this issue of Developmental Cell, Yue et al. adapted an in vivo fixation approach to isolate dormant mSCs from healthy muscle. Characterizing the transcriptome from these cells, they identified intron retention as a novel hallmark of mSC quiescence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|