AFAP1‐AS1 is upregulated and promotes esophageal squamous cell carcinoma cell proliferation and inhibits cell apoptosis

Autor:	Jingdong He, Hong‐lei Luo, Xiaofei Chen, Ming-de Huang, Xiao‐tian Xia, Jia-ni Guo, Rui-hua Fan
Rok vydání:	2016
Předmět:	Male 0301 basic medicine Cancer Research Esophageal Neoplasms Colorectal cancer AFAP1‐AS1 Apoptosis Biology noncoding RNA 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Cell Line Tumor medicine Humans Radiology Nuclear Medicine and imaging Lung cancer neoplasms malignant proliferation Cell Proliferation Neoplasm Staging Original Research Cancer Biology Oncogene Cell growth medicine.disease digestive system diseases Tumor Burden Up-Regulation esophageal squamous cell carcinoma Gene Expression Regulation Neoplastic 030104 developmental biology Oncology Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Hepatocellular carcinoma Carcinoma Squamous Cell Cancer research Female RNA Long Noncoding
Zdroj:	Cancer Medicine
ISSN:	2045-7634
DOI:	10.1002/cam4.848
Popis:	Recent findings indicate that long noncoding RNAs (lncRNAs) were dysregulated in many kinds of tumors including esophageal squamous cell carcinoma (ESCC). LncRNA AFAP1‐AS1 was found to be upregulated in hepatocellular carcinoma (HCC), lung cancer, colorectal cancer, esophageal adenocarcinoma (EAC), pancreatic ductal adenocarcinoma, and nasopharyngeal carcinoma, while its clinical value and potential function in ESCC are still unknown. Expression of AFAP1‐AS1 was measured in 65 ESCC tissues and corresponding noncancerous tissues by quantitative real‐time polymerase chain reaction, which revealed that AFAP1‐AS1 expression was markedly elevated in ESCC tissues and significantly associated with advanced TNM stage (P = 0.004) and larger tumor size (P = 0.040). Moreover, by knocking down AFAP1‐AS1 expression in ESCC cells, the proliferation and colony‐forming ability were inhibited and cell apoptosis was induced. Our data indicated the first time that AFAP1‐AS1, a novel oncogene, was remarkably upregulated and played a critical role in the progression of ESCC.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec98191c557f6bb7a4d7610d4c93c95 https://doi.org/10.1002/cam4.848 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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